MUCOADHESIVE IN SITU RECTAL GEL LOADED WITH RIFAMPICIN: STRATEGY TO IMPROVE BIOAVAILABILITY AND ALLEVIATE LIVER TOXICITY

Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity.Rectal mucoadhesive and in situ rectal gels were developed to overcome drug drawbacks.A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios.Based on the drug solubility, the selected ratio was in

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Prisons as spaces of exclusion or reconciliation

This article discusses how the aims and the social functions of prisons are reflected in their architectural designs.These are not simply economic organizations of space that Baby Wrap host relevant activities; they also communicate important political, social, and cultural meanings about crime and punishment.The article also analyzes the roles tha

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Hematopoietic Stem Cell Transplantation for the Treatment of Epstein-Barr Virus-Associated T- or NK-Cell Lymphoproliferative Diseases and Associated Disorders

Chronic active Epstein-Barr virus infection (CAEBV) is a prototype of Shark Cartilage EBV-associated T- and/or NK-cell (EBV+ T/NK-cell) lymphoproliferative disorders.Most subtypes of these are lethal.We established a unified treatment strategy composed of step 1 (immunochemotherapy: steroids, cyclosporine A, and etoposide), step 2 (multi-drug block

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Increased microerythrocyte count in homozygous alpha(+)-thalassaemia contributes to protection against severe malarial anaemia.

The heritable haemoglobinopathy alpha(+)-thalassaemia is caused by the reduced synthesis of alpha-globin chains that form part of normal adult haemoglobin (Hb).Individuals homozygous for alpha(+)-thalassaemia have microcytosis and an increased erythrocyte count.Alpha(+)-thalassaemia homozygosity confers considerable protection against severe malari

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